New Approaches in Mass Spectrometry

Mass spectrometry (MS) has evolved to become a powerful analytical tool for both quantitative and qualitative applications. The first mass spectrometer was developed in 19th century and since then it has developed from analyzing small inorganic molecules to biological macromolecules, almost with no mass limitations. Proteomics research gradually depends on MS technologies. The capability of mass spectrometry analyzing proteins and other biological extracts is due to the advances gained through the advancements in soft ionization techniques such as electrospray ionization and matrix-assisted laser desorption ionization can transform biomolecules into ions. ESI can effectively be interfaced with separation techniques enhancing its responsibility in the life and health sciences. MALDI, however has the advantage of producing individually charged ions of peptides and proteins, minimizing spectral complexity. Irrespective of the ionization source, the sensitivity of a mass spectrometer is related to the mass analyzer where ion separation takes place. Both quadrupole and time of flight mass analyzers are typically used, and they can be configured together as Q-tof tandem mass spectrometric instruments. Tandem (MS) (MS/MS), as the name signifies, is the consequence of performing two or more sequential separations of ions usually coupling two or more mass analyzers. Coupling a quadrupole and (TOF)resulted in the production of high-resolution mass spectrometers (Q-tof).

  • Metabolomics/Lipidomics: new MS technologies
  • Structural proteomics and genomics
  • Emerging separation technologies
  • Hybrid Mass Spectrometry
  • NMR Spectroscopy and NMR in biomedicine
  • Approaches in glycoproteins and glycans
  • MS Approaches in Carbohydrates, microbes and biomolecule analysis
  • Atom probe tomography
  • Protein phosphorylation and non-covalent interaction
  • Advances in isolation, enrichment and separation
  • Lipidomic, metabolomics and ultra-trace analysis
  • Nano scale and microfluidic separations
  • Complementary Techniques and Multi-technique Approaches (XPS, GD-MS)

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