Mass spectrometry in Medicinal chemistry
It is noticed that LC/MS system during the past 2 years has been used to quantify natural small molecules biologically.Numerous developments have been made in LCMS analysis such as phospholipids and drugs with respect to pharmacokinetics and pharmacodynamics studies interfering with the metabolism of sphingolipids. Simultaneous measurements of drugs with the levels of natural metabolites are designed to modify. The processes incorporated inLC-MS method development for the pharmacological studies includes three anti-cancer drugs (i.e., methoxyamine, fludarabine, and 6-benzylthioinosine). Some others being specific are tetra-enzyme cocktail utilizing for release of DNA adducts All these methods are applied to study the drug effect and drug mechanism through other integrated prospects like therapeutics and detection & determination of impurities
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